Saturday, January 24, 2009

Interpreting Lab Work

Gluten sensitive patients not only have to do their own research regarding their symptoms but they have to self-diagnose and sometimes are forced to interpret their own lab tests!

I just received the following question:

A lady in my group has the following blood work and I need help with

Tissue Transglutaminase AB is 1.2
Endomysial Antibody is Negative
Gliadin IgA is 1
Gliadin IgG is 1
IgA (Immunoglobulin A) is 152

What does this last one mean? Is that a positive reading?

She had been previously diagnosed a few years ago with DH [dermatitis herpetiformis], but the doctor never told her about the GF [gluten-free] diet, so it was just forgotten. Fast forward a few years and now she was diagnosed with MS [multiple sclerosis]. The doctor at the Cleveland Clinic told her she should go on a GF diet because she probably also has celiac.

She met with me to learn about the GF diet. I suggested she get tested
for celiac first, which she did. Soon after she was tested and read the
information I gave her, she read about the DH and then mentioned she
had already been diagnosed with that. The diet is helping, but she would like to
know the meaning of her blood work. It looks to be negative except for the
IgA, but I don't know what the normal range is for that test.

And with DH, can you test negative via regular blood testing? According to
Dr. Green, you can, but I was wondering if anyone has come across this.
She is trying to understand all this and I want to give her the correct information.

Thanks everyone,

Mansfield, OH

What a sad story. I would like to say it’s unique and uncommon but unfortunately quite the opposite is true. The lack of understanding of the damage gluten sensitivity can cause is staggering.

Here’s a woman who several years ago was diagnosed with dermatitis herpetiformis, a very uncomfortable, unsightly skin condition for which the ONLY known treatment IS a gluten-free diet and she is never told about it. Adding insult to injury the gluten she continued to eat may very well be responsible for the autoimmune, degenerative nerve disease she is now diagnosed with, multiple sclerosis.

To answer the question posed regarding lab tests, let’s take them one at a time. First I’d like to mention that if you want accurate data from a doctor regarding a lab result long distance, don’t just include the result itself but also the reference range of the test. Labs differ in this regard and a result is only as valuable as the reference range is also included.

The data below comes from our book, The Gluten Effect – available February 13, 2009.

Anti-tissue Transglutaminase Antibodies - Anti-tissue Transglutaminase Antibodies (tTG antibodies) are auto-antibodies directed against “self” tissue. After gliadin crosses the intestinal lining, a special enzyme called tissue transglutaminase binds to gliadin and takes off a portion of the protein. This portion is called glutamine. tTG antibodies are antibodies that are directed against the complex of gliadin attached to the tissue transglutaminase enzyme. tTG antibodies are 90 percent accurate in Celiac disease because they represent immune system attack at the level of the intestinal lining. Gluten sensitivity that involves minor intestinal injury or no villous atrophy will be less likely detected by tTG antibodies. Therefore, tTG antibodies correlate best with villous atrophy as several studies have supported, and a negative tTG antibody test (or EM antibody test for that matter) does not rule out gluten sensitivity when intestinal involvement is minimal or absent.

Anti-Endomysial Antibodies - Anti-Endomysial Antibodies (EM antibodies) are auto-antibodies. Gliadin is a gluten protein so therefore when the immune system attacks it, is not attacking “self” tissues but instead a foreign food protein. In contrast, as gliadin is absorbed through the intestinal lining, it attaches to the smooth muscle cells of the intestinal wall. EM antibodies are directed against proteins of these smooth muscle cells, and therefore EM antibodies are directed against “self” tissue. This defines them as auto-antibodies.Because EM antibodies attack the smooth muscle of the small intestine, these antibodies correlate better with damage to the intestine wall. Studies have supported an accuracy rate of approximately 90 percent for Celiac disease. Actually in one study, EM antibodies were present in 100 percent of individuals when total villous atrophy was present. However, EM antibodies are ineffective in detecting individuals with silent or subclinical gluten sensitivity. If minor involvement of the intestinal lining occurs or if no intestinal involvement is present, EM antibodies are much less accurate.As with Anti-Gliadin Antibodies, EM antibody testing should evaluate IgG and IgA forms of antibodies. If a gluten sensitive patient is IgA deficient, IgA EM antibodies may be falsely negative even for Celiac disease.

Anti-Gliadin Antibodies - Gliadin is the protein component of gluten that triggers the immune reactions in sensitive people, and therefore many people with gluten sensitivity have antibodies to this protein. Testing for anti-gliadin antibodies (AGA) is a simple blood test, but studies have shown that it is less sensitive for detecting Celiac disease compared to other antibodies. The confusion is that the ability of AGA to detect gluten intolerance has been defined in conjunction with a positive intestinal biopsy. While this may be a standard for Celiac disease, we now know that this is an inaccurate standard for gluten sensitivity. In fact, AGA may be the best current diagnostic test when considering all gluten related disorders. In testing for AGA, antibodies of both the IgG and IgA classes are checked since low total levels of IgA may be present. If a person has low total IgA levels, antibody tests for IgA may be falsely negative.

Total Serum IgA Level - Low total levels of IgA antibodies are rarely found in the normal population with one out of every six hundred people having this condition, but in gluten sensitivity, low IgA levels are more common. This reflects the increased IgA antibody production in the intestine to fight off gluten as it attempts to enter our bodies. If a low level of IgA is present, then certainly IgG varieties of the antibody tests described above will be more accurate in diagnosing gluten related conditions. In general, total IgA levels are not ordered often since IgG antibody tests are usually ordered concurrently. Therefore, defining a low IgA level adds little information in making a diagnosis. There is a general theory however that a lower IgA level suggests greater inflammation of the intestinal lining and greater chronicity of disease. A low IgA level may provide some insight into duration of disease.

A high serum IgA level as seen in the above test is likely indicating an infection. Increased serum IgA is common in skin, gut, respiratory and renal infections. We know this patient has DH so secondary skin infections do make sense.

The reader also asks if blood tests can be negative with DH. Yes they can. Also remember that even those diagnosed with celiac disease via biopsy show negative blood results 15% of the time.
That’s why the moral of the story at this time is to evaluate how you feel when you eat 100% gluten-free for a couple of months. Until we have highly sensitive tests we can rely on to accurately diagnose gluten sensitivity, diagnosing will involve “building a case” by pulling together many pieces of information about the patient including symptoms, response to a gluten-free diet, lab tests, genetic history, presence of intestinal infections, etc.

This leads us to explain some things about this particular patient. She has known DH which is solely due to gluten intolerance, yet it can be present with negative blood tests. Does that make the diagnosis or need for a gluten-free diet in question? Not at all. She is now diagnosed with MS. We know that, second to the digestive tract, the most common system to be affected by gluten is the nervous system with autoimmune diseases occurring at a very high rate. Does the negative test ensure that gluten had nothing to do with the development of MS? No, it doesn’t. We’d need to know a lot more about this patient (which by the way is the most difficult part of hearing from readers long distance – I want more data.) but I wouldn’t be surprised to find other factors which point to gluten as the culprit.

To Your Good Health!

Dr Vikki Petersen


Anonymous said...

Was told im not celiac....But I feel horrible. What do you think?

Found my old results:
Gliadin Antibody IGG 31 High Range <11
Gliadin Antibody IGA 6 Range <6

Reticulin igg ab <1:10 Range <1:10
Reticulin IGA AB <1:10 Range <1:10
Tissue Transglut. IGA <3 Range <5

Then last year Everything the same but Gliadin IgG 23.4 High Range <10

What does it mean that eveything is normal BUT the Gliadin IgG?

The HealthNOW Doctors said...

I cannot diagnose you over the internet, of course, but I can tell you that the test the was performed was looking for indicators of both celiac disease and gluten sensitivity. That's good.

And while the celiac indicators are negative, gliadin antibody testing, whether IgG or IgA, is an indicator of gluten sensitivity.

I would be happy to assist you with more specific advice. Just give us a call for a free health analysis. Call 408-733-0400.

To your good health,
Dr Vikki

Anonymous said...

My daughter recently had the following blood work results. These were ordered by General Doctor as she was experiencing diarehha. No other major symptoms. The results were/are:
Gluten Sensitivity Panel
Endomysial Ab IgA negative

Tissue Transglutaminase Antibody
t Transglutaminase Ab IgA 23* 0-20 EU/ml

She was advised that she is allergic to all glutens.
Is that correct?

She has been referred for an ?endoscopic examination with a specialist.

Also does being a vegan contribute to this?

Please let us know about the results.

Thanks very much
: )

The HealthNOW Doctors said...


A positive tTG test is indicative of celiac disease. You doctor is recommending a biopsy to confirm that diagnosis.

Even if the biopsy comes out negative, there has to be a reason the tissue of your daughter's small intestine is being destroyed.

If the biopsy is positive then there is no argument, of course, but do let me know if any confusion arises should the biopsy be negative.

Do understand that celiac is a genetic disease and being a vegan has absolutely nothing to do with its development. Personally I am pro-vegan, but that's beside the point.

If it critical that your daughter avoid all gluten plus get assistance in healing her gut. Typically general doctors don't excel at that.

Feel free to call me for a free health analysis and we can discuss specifics - 408-733-0400.

Your daughter can enjoy excellent health if the right things are done now. By the way, the rest of the family should be checked also - it is a genetic disease.

Dr Vikki

Patricia V said...

I have been having stomach issues. I went for a blood test and they performed a celiac disease panel. This is the results:
Transglutaminase IgG <15
Transglutaminase IgA 27.3

Gliadin IgG: <15
Gliadin IgA <15

My primary dr. said he thinks I have Celiac Disease (and so does my mother). He wants me to make an appt with a Gastrointerologist. Just by the numbers (after all my research) it looks like Celiac. Transglutaminase is elevated isn't that indicative of Celiac? I am just confused by the might.

Any thoughts?

Patricia V said...

I have been feeling lousy and so my dr did a blood test to check for Celiac since my mother has it. When he called me back he said I need to see a Gastrointerlogist because I probably have Celiac. He sent my my resuls and I am a little confused after doing some research.

These are my results.

Transglutaminase IgG <15
Transglutaminase IgA 27.3

Gliadin IgG <15
Gliadin IgA <15

Using numbers only since you don't know me. Do I have Celiac? I am a little confused when my primary care dr says I may have Celiac.

Any opinions until I see the gastro dr would be great!

Anonymous said...

What are abnormal results? My tests. were tissue Transglutaminase igG
0.15. IgA 0.50 is this celiac??

The HealthNOW Doctors said...

It depends on the lab. There is a normal range. Anything above that would be highly suspicious.

If you want to give me more data I'd be happy to help with further questions.

Dr Vikki

The HealthNOW Doctors said...

Dear Patricia V,
Yes, you are correct. An elevated tTG level IS indicative of celiac disease.

Too often, even positive tests are not acted upon aggressively by clinicians who aren't expert in the area of gluten.

Please consider calling us for a free health analysis. We are here to help! Call 408-733-0400.

Dr Vikki

Anonymous said...

This are my test results:

Gliadin Ab (IGA) 49
units (<20)---[Is it very high? What would be the highest number?]
Gliadin Ab (IGG) 13

>or 20 Antibody detected

Endomysial Ab Scrn: Positive

Those were tests I had for celiac. Doctor told me to go on gluten free diet since tests are positive for celiac disease. But what does it mean that IGG is negative? And IGA 49 confirms celiac?
I didn't have a biopsy performed. I am 4 months on gluten free diet and I am not feeling better. :(

Thank you

The HealthNOW Doctors said...

@ Ada,
It is the positive endomysial test that is causing your doctor to diagnose celiac disease.

The AGA tests, one of which is positive is indicative of gluten intolerance, but doesn't make a distinction between celiac and gluten sensitivity. But with the endomysial positive, that indicates celiac.

Understand that anything positive is positive.

Either you have celiac or you don't. There's no such thing as 'mild celiac' or 'a little celiac'. In other words, whether the number was 21, 31 or 81, it wouldn't matter - the point is that it's positive.

The reason you don't likely feel better is that the secondary effects associated with gluten are not being addressed for you.

That is our specialty and it's not difficult to address. If you'd like help please consider calling us for a free health analysis. Call 408-733-0400 - we are here to help.

Dr Vikki

Anonymous said...

I have a transglutaminase IgG of 34.7 which said 15 is average. The endomysial Iva is negative. Tirer is negative. Immounoglobulin a is 136. Primary said maybe is celiac. Gastronomic said both could be false positives need to do endoscopy. I have to go to specialist but why is level high and do u think this is celiac. Any other blood test that could help diagnose with endoscopy. Thank you

The HealthNOW Doctors said...

The positive tTG is quite suspicious of celiac disease. I don't know what your symptoms are but a biopsy is a way to confirm.
With that said, do understand that biopsies are not perfect and it is possible to have celiac disease with a negative biopsy.
If you'd like a free health analysis so that I can better understand your health status, you are welcome to do so. Call 408-761-3900.
It is very important that you find out conclusively if a gluten-free diet is something that you need to implement.
I'm happy to assist you.

Anonymous said...

My results are:
Transglutaminase Ab (Iga) <3
IGA SERUM 52 low
c-reactive is high
speckled 1:80
Feel awlful, weight gain, have high blood pressure,imflammation and pain.

The HealthNOW Doctors said...

Dear Anonymous,
When you're general IgA results are low, any test utilizing that immunoglobin will be false. Therefore we cannot tell whether you have a positive tTG or not. It's too bad that the lab did not also measure IgG. Most labs these days do that for this exact reason.
The high C-reactive protein shows inflammation, so it is important to figure out where that it coming from.
You can contact us for a free health analysis (408-733-0400) if you'd like.
Dr Vikki

Anonymous said...


My mother has celiac disease and I been having stomach pain a day or two after eating wheat product. I was tested and the results are confusing;

IMMUNOGLOBULIN A 248 mg/dL [46-287]

Can you advise if this may be false negative? Why is the IgA so low?


The HealthNOW Doctors said...

It's not actually confusing, just potentially incomplete.
The tTG is negative and the IgA is normal too. While one could say this is a negative celiac test, it really should include a blood test for anti-gliadin antibodies and deaminated giadin - 2 more blood tests used in a celiac panel.
It is unfortunate that we don't have one perfect test, but we don't. Another great test, if you're still consuming gluten is Cyrex Labs comprehensive profile for both celiac and gluten sensitivity.
You obviously feel poorly after eating gluten, now we just need to find out if you're gluten sensitive or celiac. A genetic test is another option.
Hopefully I'm not confusing you!
If you'd like a free health analysis where we could speak more personally, consider calling us at 408-733-0400.
Dr Vikki

Rosanne Zimmerman said...

Hello Dr. Vikki

My daughter is gluten sensitive and was having general ill health and CNS problems ie. muscle ticks. Gluten free two month and lost 20lbs and said she did not know she could have so much energy. Muscle ticks are minute now. Anyways before going gluten free we did have the celiac test done. Gliadin AB: IgA was <3(ref 0-20), Gliandin AB: IgG was 5(ref0-20) and Tissue Transglutaminase was 3(ref 0-20). Now I get these numbers are below the ref range for celiac and I know due to a gluten free diet she is sensitive or intolerant. I am just trying to interpret her numbers. Her neurologist said the if she did not have gluten intolerance then she would not have antibodies. Is this true? Would a healthy person without gluten problems have 0 antibodies. Does the indication of any antibodies indicate gluten sensitivity? I am reading your wonderful book and just trying to understand all of this as I just had my testing done as well. I was gluten free before having the test done so may not be so accurate but read that as long as one is not gluten free more than 6 months they can still have blood test do to antibodies still being produced. Is that true? Just want to know how to interpret my tests when they come back. This is so complex. I recommend your book to everyone. Very easy to read on such as complex issue.

Anonymous said...

I recently had blood work done because my dr suspects I have celiac. Here are my blood work results:


IMMUNOGLOBULIN A 508 (Standard Range is 81-463 mg/dL)


My doctor said she thinks it's positive for celiac but suggested I follow up with a GI doctor.

I can see by IGA is above standard range, but what do the other numbers mean? They both seem to indicate that there is no antibody detected - does that mean it is positive for celiac?

Any thoughts would be appreciated!

Anonymous said...

I recently had blood work done because my dr suspects I have celiac. Here are my blood work results:


IMMUNOGLOBULIN A 508 (Standard Range is 81-463 mg/dL)


My doctor said she thinks it's positive for celiac but suggested I follow up with a GI doctor.

I can see by IGA is above standard range, but what do the other numbers mean? They both seem to indicate that there is no antibody detected - does that mean it is positive for celiac?

Any thoughts would be appreciated!

The HealthNOW Doctors said...

The tTG is definitely negative at 1, but depending on the lab used, I don't know if the AGA at 11 is considered to be positive. It would be for my lab but different labs have different reference ranges.

The IgA is a bit high indicating some immune system stress, but unclear as to why at this point.

So, I need more data. Also, realize that these tests aren't perfect so a negative test could still mean a positive gluten intolerance.

I know that's a little frustrating, but we can figure it out. If you'd like assistance please consider calling us for a free health analysis - 408-733-0400.

yasmin said...

my 4 yearold daughter was diagonised for celiac disease 1 year before.she was confirmed after a biopsy. Since then she eats gluten freefood.After 6 mnths her endomysium Abs (IgA)become has dropped down from >200 which was at the time of after an year her level is 13.47.i wud like to know y it has increased?

The HealthNOW Doctors said...

Dear Yasmin,
Each lab has different reference ranges. Is the '13' above the reference range? In other words was 5 negative and is the 13 positive?

If the 13 is still below the reference range, I wouldn't be concerned. As long as the number is negative, your daughter is doing well.

If the 13 is positive, then I would be looking at contamination, hidden gluten and potentially cross-reactive food reactions.

Consider contacting us for a free health analysis if you would like some assistance figuring it out. Call 408-733-0400.

Dr Vikki

Anonymous said...

My Tissue Transglutamianse IgA serum result is 23.05, range is <18. does it mean i have celiac disease?

Anonymous said...

My Tissue Transglutamianse IgA result is 23.05, range is <18. does it mean i have celiac disease?

The HealthNOW Doctors said...

It is quite suspicious. What does your doctor say? Do you have symptoms of celiac disease? Can you get a genetic test? Does celiac disease run in your family?

As you can see I have many questions. Please feel free to write back.

Anonymous said...

i would so much appreciate help with labs.pediatrician ran celiac panels and kids were under 19(=negative) for tTG igG and tTG IgA, so the lab did not perform the endomys igA. they tested under 19(=negative) for dgp IgG and igA, too.i am still worried because i have two dq8's, out of range occludin/zonulin IgM and lipopolysaccarides IgM. my transglutaminase-6 IgG is 2.29(should be below 1.5).can my kids still have transglutaminase-6 damage from other proteins that they need tested for?

anonymous said...

I asked for gluten blood tests at a private lab on my own (without a doctor) because I'm living overseas right now. This was after reading symptoms online. Can someone help me interpret the results?

IgA 1,7
IgG 0,9
Anti-IgA 19,4
Anti-IgG 3,0


The HealthNOW Doctors said...

Dear Anonymous,
Labs have reference ranges - meaning a range that they consider normal. You'd need to include that information for me.

Was the IgA for tTG, endomysial, anti-gliadin? That seems to be missing as well.

You need to look carefully at the report that you received and include all the data.

Dr Vikki

Anonymous said...

thank you for your help.
Yes it has references which I found difficult to understand. Here they are with my numbers there also:

IgA 1,7 antibodies to tissue transglutaminase
negative: 0,0-10,0 U/ml positive: => 10,0 U/ml

IgG 0,9 antibodies to tissue transglutaminase
negative: 0,0-10,0 U/ml positive: => 10,0 U/ml

Anti-gliadin IgA 19,4
negative: 0,0-12,0 U/ml positive: => 12,0 U/ml

Anti-Gliadin IgG 3,0
negative: 0,0-12,0 U/ml positive: => 12,0 U/ml

Anonymous said...

Apologies if you receive this 2x-hadn't logged on.
Thank you for helping! Here is is again with the references:

1,7 IgA antibodies to tissue transglutaminase
Negative 0,0-10,0 U/ml Positive >/= 10,0- U/ml

0,9 IgG antibodies to tissue transglutaminase
Negative 0,0-10,0 U/ml Positive >/= 10,0- U/ml

19,4 Anti-gliadin IgA
Negative 0,0-12,0 U/ml Positive >/= 12,0- U/ml

3,0 Anti-gliadin IgG
Negative 0,0-12,0 U/ml Positive >/= 12,0- U/ml

Elisa (test name?) written under numbers

The HealthNOW Doctors said...

The positive result is the AGA IgA. This test being positive is consistent with gluten sensitivity, although it is possible to be positive in celiac disease. With the other results being negative the more likely disorder is gluten sensitivity but this would need to be corroborated with other information.
I cannot diagnose you over the internet, of course, but if you'd like some assistance, consider contacting us for a free health analysis - call 408-733-0400.
We are here to help!

The HealthNOW Doctors said...

Dear Anonymous asking about your children. Yes, they could have tTG-6 possibly. Have you done genetic testing on the children.
That might be a good place to go next.
If you need assistance, consider calling us for a free health analysis - 408-733-0400. We are here to help!

Anonymous said...

Hi - I think I'm dealing with the opposite problem of most people here. My lab results seem to say that, if anything, I only have a mild gluten allergy yet I have a doctor saying I can never eat wheat, gluten or dairy again for the rest of my life (the last shows in very low positive - just .06 over the Equivocal range into 'Out of Range' - and Equivocal ranges on a Cyrex lab).

I have LabCorp tests:

Deamidated Gliadin Abs, IgA=4 units (1-19 Negative; 20-30 Weak Positive; >30 Moderate to Strong Positive)

Deamidated Gliadin Abs, IgG=2 units (1-19 Negative; 20-30 Weak Positive; >30 Moderate to Strong Positive)

t-Transglutaminase (tTG) IgA = <2 U/ml (0-3 = Negative; 4-10 Weak Positive; >10 Positive)

t-Transglutaminase (tTG) IgG = <2 U/ml (0-5 = Negative; 6-9 Weak Positive; >9 Positive)

Endomysial Antibiody IgA Negative

Immunoglobulin A, Qn, Serum = 222 mg/dl (91-414 Limit range)

Is this doctor trying to hit me with a "Every problem is Gluten sensitivity or Celiacs!" hammer when that's not my problem? (I'm also fighting Lymes Disease.)

The HealthNOW Doctors said...

Dear Anonymous,
I understand your confusion; let me explain. The Lab Corp results you cite are for celiac disease and those are negative.

The Cyrex test you received, based on the value you gave me, is stating positive for gluten sensitivity. I know Cyrex quite well and they feel that anything in the 'equivocal' range, let alone the 'positive' one is cause for serious consideration. In other words, even if you hadn't just barely crossed out of equivocal into out of range, your doctor would still likely have recommended you go gluten-free and I don't disagree.

Have you tried it? Do you feel better on a gluten-free diet? These too are valid questions.

It's hard to give you more information without a conversation. If you'd like a free health analysis, consider calling us at 408-733-0400.

I hope that helped!

Dr Vikki

Anonymous said...

Thanks, Dr. Vikki!

I've asked for Cyrex Array 3 to be done (that was never done) and I think that will clear things up for me. Your explanation helps as well. So, not Celiac but mild gluten crossover allergies given the following:

- Cow's Milk 1.11 (Noted as Equiv; - range=0.1-1.3)
- Casein 1.26 (range=0.1-1.2)
- Casomorphin listed as negative at 0.58 even though the range=0.2-1.6???? What the heck?? Why is this not listed as Equiv?)
- Milk Butyrophilin 1.15 (Noted as Equiv; range=0.1-1.3)
- Whey Protein 1.35 (range=0.1-1.3)
- Chocolate (milk) 1.01 (Noted as Equiv; range=0.1-1.4 - thank goodness I like dark chocolate which I was told is ok)
- Coffee 2.30 (range=0.2-1.2 - was told this is only for instant coffee but I rarely have more than a sip of good quality coffee a month so no big loss)
- Sesame 2.79 (range=0.1-1.3)

Oddly, while Sesame is my strongest response, I'm told I can not have any for 6 months and then I can try adding it back in. Dairy response numbers are so much lower and yet Sesame is going to be ok with me in 6 months vs. dairy is something I'm never again supposed to have?? That and the value vs. the range of Casomorph make no sense to me.

I've seen some Cyrex array 4 lab results online where 80% or more are listed as problems so I'm told I'm lucky. That being said, I did great on SCD which includes butter, hard cheeses, and homemade yogurt that's been fermented 30+ hours. I stopped living that way 100% of the time because it was a) expensive, b) inconvenient, and c) time consuming.

While I absolutely do better keeping dairy (and even wheat) in moderation, I certainly don't wreck myself when I have the occasional ice cream or grain product. In fact, when I am regularly working out, I don't seem to have any problems with such things at all. Further, I don't have a problem with these foods when I'm overseas (but, for grain products, that's more to do with an inability to use folic acid and being MTHFR C677T homozygous - another kettle of fish. Thyroid is mixed in there too as I hurt when I eat these things if I'm not on T3/T4 but, again, only in the United States - I don't have a thyroid issue while in 4 other countries I've been for work.

Annie Garrie said...

Hi, both my sons were told to go on gluten free diet after one of the four tests had come back pos. I don't know what test came back pos for my oldest, but I am going to get to the bottom of that soon. My other sons IgG was 56. What exactly does this mean? Everything else is normal range. I have been reading up and it scares me that he may not have celiac, but maybe a different autoimmune disease. I have him on a gf diet for 3 months now, and not sure what to do next to make sure this is all we need to do. Please help

Annie Garrie said...

Hi, I just was told my sons IgG was what came back pos on his Celiac panel. His IgG was 56, and I'm not sure what exactly that means. I was told put him on a gf diet. I did more research online and am now wondering if it's possible with it being so high that he may have a different autoimmune disease. What are your thoughts?

The HealthNOW Doctors said...

Hello Annie,
I'm sorry for the delay in getting back to you. We get a lot of traffic and every once in a while an email gets missed, I apologize.

I would need more information in order to answer your question. IgG is a part of the immune system, not the name of the test. There would be more to it. Also a "56" doesn't mean much without the reference range.

I know as a parent how frustrating it can be to not fully understand or get answers as regards your children's health.

I would like to offer you a free health analysis (just call 408-733-0400) and then we can talk and I can better assist you and your children.

I look forward to hearing from you.

The HealthNOW Doctors said...

Hello again Annie,
Well I no sooner post my last comment and another question appears from you that did clarify things quite a bit.

So it was a celiac test and "56" was quite high - got it. There are other criteria to use to determine if it's truly celiac and do know that a biopsy doesn't have to be one of them as it in quite invasive for a child.

As I mentioned earlier, I'd be happy to discuss it further with you over the phone and I can give you specific ideas of how best to proceed.

The HealthNOW Doctors said...

I cannot give medical advice to you over the internet but speaking generally, I can give you some ideas. The positive amongst these is the anti-gliadin antibody, IgA. While not conclusive, this test is often used as an indicator for gluten sensitivity.
I'm assuming you were eating gluten at the time of the test- correct?

The best next step I could suggest is to consider contacting us for a free health analysis - call 408-733-0400. That way we could speak directly and I could get more information.

I wouldn't ignore these results. I would behoove you and your health to find a clinician who is an expert in this field if you choose not to contact us.

Good luck!

The HealthNOW Doctors said...

@Roseanne- Gluten tests aren't really accurate if you're perfectly off it much beyond 3 weeks after elimination.

As regards your daughter, did the test her total IgA. I'm wondering if the total was low - that would skew her tests. Low IgA is quite common in those w/ gluten issues.

I'm glad you enjoy the book!

If you or your daughter needs some assistance, consider contacting us for a free health analysis - call 408-733-0400. Then we can speak and create the best approach to optimize your and her health.

We are here to help!

Anonymous said...

I just received results from a celiac panel and am having a hard time interpreting the results based on the research I've done.

gliadin antibody iga 4 (less than 20 is normal)
gliadin antibody igg 3 (less than 20 is normal)

ttg iga 5 (less than 20 is normal)
ttg igg 4 (less than 20 is normal)

According to this report everything is normal...but in some of my research it looks like Iga levels less than 7 indicate another problem. Am I misunderstanding my research?

The HealthNOW Doctors said...

Hello Anonymous,
What you are thinking of is that if the total IgA is low then tests measuring IgA such as the tTG and AGA can be falsely negative.

This is true. It doesn't appear that they tested your total IgA. At least you don't mention it.

So your tests could very well be negative, but without the total IgA number we can't know for sure.

Let me know if you need any assistance.

Anonymous said...

Hi please can you help decipher my blood test results.
Tissue transglutaminase IgA level =1.8 kU/L (<5.0) and IgM = 0.76 g/L and IgA= 2.76 g /l and IgG =14.2 g /L.

I was told to go on gluten free diet the month before.
Doctor said my previous Tissue Transglutaminase IgA level was 17.9 kU/L. So its come down greatly to 1.8. I'm still confused as she fully explain my results. Please can you help? Thanks.

Anonymous said...

Hello I just received my blood results
Tissue Transglutiminase, 0.4

Tissue Transglutimnase, IgG <0.6

Gldn Antibody,IgA(Deamid) 1.0

Gldn Antibody,IgG(Deamid) <0.4

Anonymous said...

Tissue Transglutiminase, IgA <7 IU/mL 0.4
Tissue Transglutimnase, IgG <7 IU/mL <0.6
Gldn Antibody,IgA(Deamid) <7 IU/mL 1.0
Gldn Antibody,IgG(Deamid) <7 IU/mL <0.4

Positive or negative??

Anonymous said...

Tissue Transglutiminase, IgA <7 IU/mL 0.4
Tissue Transglutimnase, IgG <7 IU/mL <0.6
Gldn Antibody,IgA(Deamid) <7 IU/mL 1.0
Gldn Antibody,IgG(Deamid) <7 IU/mL <0.4

The HealthNOW Doctors said...

@ Anonymous who recently posted. All the values you wrote down are negative.
That doesn't necessarily mean you don't have a problem w/ gluten as there are more comprehensive tests, but the ones you cite are negative.

If you're having health difficulties and want to get to the root cause of what's happening, consider contacting us for a free health analysis (call 408-733-0400). We are here to help and treat patients from across the country and internationally.

The HealthNOW Doctors said...

@Anonymous whose doctor stated the tTG level for IgA has come down:
The IgG level is still elevated based on the values you wrote down.

I would be happy to help. My best suggestion is to call us for a free health analysis (call 408-733-0400) so that we can discuss how you're feeling and what you've done thus far.

We are a destination clinic and treat patients from across the country and internationally. We are here to help!

I look forward to hearing from you.

Amy said...

My 3 year old son was just tested. His older sister has confirmed Celiac. Two years ago, his test was negative. This is now his panel:

Total Serum IgA: 30 (44-189)
Gliadin IgA AB: 6 (No reference)
Gliadin IgG AB: 21 (High)
Transglutaminase IgA AB <2 (0-3)
Translutaminase IgG AB 6 (0-5)
Endomysial AB IgA Negative

Help! What does this mean??

The HealthNOW Doctors said...

Hello Amy,

I understand your confusion. I very much want to help you and your son.

Please consider contacting me at the clinic for a free health analysis - it's no charge and then we can speak. It's a better format than this one to ensure I answer all your questions.

Just call 408-733-0400.

I look forward to hearing from you!

Dr Petersen